Mouse model Myostatin Heart Acetylcholinesterase deficiency Aging Myelin Knockout Centronuclear myopathy Diaphragm Cell culture model Myotonic Dystrophy BIOLOGIE MOLECULAIRE GABA Muscular dystrophy KNOCKOUT MICE RNA splicing Brain dysfunction Exercice Alternative splicing Hypoxia CMS Long read sequencing Muscle Antisense oligonucleotide Antisense oligonucleotides Intermediate filament Dynamin 2 Cell penetrating peptide Exercise Autophagy Oligodendrocyte Acute coronary syndrome Humans Maximal force CTG repeat instability GSK3␤ DMSXL mice Dystrophie Myotonique Myotonic dystrophy type 1 DM1 Cytoskeleton Neuron Therapy Glucocorticoids Myotonic Dystrophy type 1 MBNL Transgenic mouse model PacBio Myotonic dystrophy mouse models Skeletal muscle Mouse models Genotype phenotype correlation Glutamate Heart failure CRISPR/Cas9 CTG repeat contractions Transgenic mouse Central nervous system CTG repeats Gene therapy ARN Fibrosis Glial cells RNA biology Animals Quantitative microdialysis PCR Dystrophin Myotonic dystrophy Astrocyte Gene editing Duchenne muscular dystrophy DMPK Thérapie génique In vivo Dystrophie myotonique Male Astrocytes Trinucleotide Repeat Expansion Trinucleotide repeat expansion Transcriptomics Cell model AAV RNA interference Dilated cardiomyopathy Desmin CRISPRi Myotonic Dystrophy Type 1 Expression ACETYLCHOLINESTERASE Cardiac muscle Endurance training Acetylcholinesterase knockout mouse Mice CONGENITAL MYATHENIC SYNDROME Glucocorticoid-receptor Gene Therapy Oligodendrocytes Motoneuron Brain