Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?

Abstract : The hematocrit-to-viscosity ratio (HVR) has been widely used has an estimate of red blood cell (RBC) oxygen transport effectiveness into the microvasculature or as an oxygen delivery index. However, no study investigated the possibility of HVR to truly reflect RBC oxygen transport effectiveness or to be an oxygen delivery index. We measured blood viscosity at high shear rate (225 s −1), hematocrit, HVR, as well as the microvascular oxyhemoglobin saturation (TOI; tissue oxygen index) by spatial resolved near-infrared spectroscopy (NIRS) at cerebral and muscle levels in three population known to have various degrees of hemorheological abnormalities: healthy subjects (AA), patients with sickle cell SC disease (SC) characterized by moderate anemia and patients with sickle cell anemia (SS) marked by severe anemia. At both the cerebral and muscle level, HVR was positively correlated with TOI (r = 0.28; p = 0.03 and r = 0.38; p = 0.003, at the cerebral and muscle level, respectively). These findings suggest that HVR probably play a key role in blood flow and hemodynamic regulation in the microvasculature, hence modulating the amount of oxygen available for tissues. Nevertheless, the strengths of the associations are weak (R 2 < 0.50), suggesting that other determinants modulate microvascular blood flow and oxygenation, such as vascular geometry and vasomotor reserve.
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Article dans une revue
Clinical Hemorheology and Microcirculation, IOS Press, 2015, 59, pp.37-43. 〈10.3233/CH-131742〉
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https://hal.univ-antilles.fr/hal-01163460
Contributeur : Philippe Simon <>
Soumis le : vendredi 12 juin 2015 - 21:11:23
Dernière modification le : mercredi 18 juillet 2018 - 20:11:27

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Xavier Waltz, Marie-Dominique Hardy-Dessources, Nathalie Lemonne, Danì Ele Mougenel, Marie-Laure Lalanne-Mistrih, et al.. Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?. Clinical Hemorheology and Microcirculation, IOS Press, 2015, 59, pp.37-43. 〈10.3233/CH-131742〉. 〈hal-01163460〉

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