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Journal articles
Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study
Céline Renoux
1
Marc Romana
2
Philippe Joly
1
Séverine Ferdinand
3
Camille Faes
1
Nathalie Lemonne
4
Sarah Skinner
1
Nathalie Garnier
Maryse Etienne-Julan
4
Yves Bertrand
5
Marie Petras
6
Giovanna Cannas
7
Lydia Divialle-Doumdo
6
Elie Nader
1
Daniela Cuzzubbo
Yann Lamarre
8, 9
Alexandra Gauthier
Xavier Waltz
9, 8
Kamila Kebaili
10
Cyril Martin
1
Arnaud Hot
11
Marie-Dominique Hardy-Dessources
8, 9
Vincent Pialoux
1
Philippe Connes
1
Bamidele O. Tayo
Céline Renoux 1
Author
Marc Romana 2
Author IdHAL : marc-romana ORCID : https://orcid.org/0000-0002-8715-9836
Philippe Joly 1
Author
Séverine Ferdinand 3
Author
Alexandra Gauthier
Author
Xavier Waltz 9, 8
Author
Kamila Kebaili 10
Author
Cyril Martin 1
Author IdHAL : cyril-martin ORCID : https://orcid.org/0000-0003-3378-5249
Arnaud Hot 11
Author
Marie-Dominique Hardy-Dessources 8, 9
Author
Vincent Pialoux 1
Author
Philippe Connes 1
Author IdHAL : philippe-connes ORCID : https://orcid.org/0000-0002-9232-0268
Bamidele O. Tayo
Author
1
LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité (CAMPUS SANTE INNOVATIONS - Bâtiment IRMIS - 10 rue de la Marandière 42270 Saint Priest en Jarez /
Université Savoie Mont Blanc - Campus Scientifique - 73370 Le Bourget du Lac / UFR STAPS - Université Claude Bernard Lyon I - 27/29 Boulevard du 11 novembre 1918 - 69622 Villeurbanne Cedex - France)
- USMB [Université de Savoie] [Université de Chambéry] - Université Savoie Mont Blanc : EA7424 (27, rue Marcoz - 73000 Chambéry - France)
- UCBL - Université Claude Bernard Lyon 1 : EA7424 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- UJM - Université Jean Monnet [Saint-Étienne] : EA7424 (10 rue Tréfilerie - 42100 Saint-Étienne - France)
2
UAG - Université des Antilles et de la Guyane (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
3
Observatoire Régional de la Santé de la Guadeloupe (Basse-Terre, Guadeloupe - Guadeloupe)
4
Unité Transversale de la Drépanocytose (BP 465 - 97159 Pointe-à-Pitre Cedex - Guadeloupe)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
5
UMR AGAP - Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (TA A-108 / 03 - Avenue Agropolis - 34398 Montpellier Cedex 5 France - France)
- INRA - Institut National de la Recherche Agronomique : UMR1334 (France)
- Montpellier SupAgro - Institut national d’études supérieures agronomiques de Montpellier (2, place Viala 34060 Montpellier Cédex 2 - France)
- Montpellier SupAgro - Centre international d'études supérieures en sciences agronomiques (2, place Pierre Viala - 34060 Montpellier Cedex 02 - France)
- Cirad - Centre de Coopération Internationale en Recherche Agronomique pour le Développement : UMR108 (Siège 42, rue Scheffer 75116 Paris - France)
6
Unité Transversale de la Drépanocytose (BP 465 - 97159 Pointe-à-Pitre Cedex - Guadeloupe)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
7
Hôpital Edouard Herriot [CHU - HCL] (5 Place d'Arsonval
69003 Lyon - France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
8
Labex Gr-Ex - Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Imagine Institute
24, Boulevard du Montparnasse
75015, Paris - France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- USPC - Université Sorbonne Paris Cité (Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
9
BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge (6 rue Alexandre Cabanel - 75739 Paris cedex 15 - France)
- INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_S_1134 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- UR - Université de La Réunion (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
- UA - Université des Antilles (Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1134 (101, rue de Tolbiac, 75013 Paris - France)
10
Institut d’Hémato-Oncologie Pédiatrique (Lyon - France)
11
Service de Médecine Interne (CHU Edouard Herriot (HCL), Service de Médecine Interne, F 69437 Lyon, France - France)
- Hôpital Edouard Herriot [CHU - HCL] (5 Place d'Arsonval
69003 Lyon - France)
- HCL - Hospices Civils de Lyon (3 Quai des Célestins 69002 Lyon - France)
Abstract : OBJECTIVES:
Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown.
MATERIALS AND METHODS:
Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients.
RESULTS:
Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age.
CONCLUSION:
The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.
Document type :
Journal articles
Domain :
Complete list of metadata
https://hal.univ-antilles.fr/hal-01669747
Contributor : Marc Romana <>
Submitted on : Thursday, December 21, 2017 - 12:21:58 AM
Last modification on : Tuesday, September 7, 2021 - 3:36:42 PM
Contributor : Marc Romana <>
Submitted on : Thursday, December 21, 2017 - 12:21:58 AM
Last modification on : Tuesday, September 7, 2021 - 3:36:42 PM
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Distributed under a Creative Commons Attribution 4.0 International License
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Identifiers
- HAL Id : hal-01669747, version 1
- DOI : 10.1371/journal.pone.0158182
- PUBMED : 27355589
- PUBMEDCENTRAL : PMC4927160
Collections
UNIV-AG | INRA | HCL | HEH | AGROPOLIS | CIRAD | INSERM | UNIV-LYON1 | UNIV-ST-ETIENNE | UNIV-SAVOIE | UNIV-PARIS7 | USPC | LIBM | MONTPELLIER-SUPAGRO | UDL | INRAE | UNIV-PARIS | UP-SCIENCES | INRAEOCCITANIEMONTPELLIER | AFRIQ | UGA
Citation
Céline Renoux, Marc Romana, Philippe Joly, Séverine Ferdinand, Camille Faes, et al.. Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study. PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0158182. ⟨10.1371/journal.pone.0158182⟩. ⟨hal-01669747⟩
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