New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises

Claudine Lapouméroulie 1 Philippe Connes 2 Sara El Hoss Régine Hierso 1 Keyne Charlot 3 Nathalie Lemonne 4 Jacques Elion 5 Caroline Le van Kim 6 Marc Romana 7 Marie-Dominique Hardy-Dessources 7
1 BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge
2 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
3 ACTES - Adaptation, Climat Tropical, Exercice et Santé
4 Unité Transversale de la Drépanocytose
5 Insern, UMR 763, Hôpital Robert Debré
6 Protéines de la membrane érythrocytaire et homologues non-érythroides
7 Pharmacogénétique et abords thérapeutiques des maladies héréditaires
Abstract : Painful vaso-occlusive crisis (VOC) represents the most frequent complication encountered by SCA patients. In animal models, increased red blood cell (RBC) adhesion to the endothelium has been demonstrated to initiate VOC by increasing the transit time of RBC through the microcirculation, predisposing them to sickle and occlude the vessels (Kaul et al.,
Keywords : sickle cell anaemia vaso-occlusive crisis blood rheology irreversibly sickled cells adhesion
Document type :
Journal articles
Complete list of metadatas
https://hal.univ-antilles.fr/hal-01968397
Contributor : Marc Romana <>
Submitted on : Wednesday, January 2, 2019 - 4:41:20 PM
Last modification on : Thursday, December 12, 2019 - 1:54:18 PM

Files

Lapoumeroulie et al mr.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01968397, version 1

Collections

UNIV-AG | UNIV-ST-ETIENNE | UNIV-LYON1 | UNIV-SAVOIE | UGA | UNIV-PARIS7 | USPC | LIBM | UDL

Citation

Claudine Lapouméroulie, Philippe Connes, Sara El Hoss, Régine Hierso, Keyne Charlot, et al.. New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. British Journal of Haematology, Wiley, In press. ⟨hal-01968397⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

185

Files downloads

225

Contact

Informations

CCSD