New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises

Abstract : Painful vaso-occlusive crisis (VOC) represents the most frequent complication encountered by SCA patients. In animal models, increased red blood cell (RBC) adhesion to the endothelium has been demonstrated to initiate VOC by increasing the transit time of RBC through the microcirculation, predisposing them to sickle and occlude the vessels (Kaul et al.,
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https://hal.univ-antilles.fr/hal-01968397
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Submitted on : Wednesday, January 2, 2019 - 4:41:20 PM
Last modification on : Tuesday, November 19, 2019 - 2:37:36 AM

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  • HAL Id : hal-01968397, version 1

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Claudine Lapouméroulie, Philippe Connes, Sara El Hoss, Régine Hierso, Keyne Charlot, et al.. New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. British Journal of Haematology, Wiley, In press. ⟨hal-01968397⟩

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