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New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises

Claudine Lapouméroulie 1 Philippe Connes 2 Sara El Hoss Régine Hierso 1 Keyne Charlot 3 Nathalie Lemonne 4 Jacques Elion 5 Caroline Le van Kim 6 Marc Romana 7 Marie-Dominique Hardy-Dessources 7
1 BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge
2 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
3 ACTES - Adaptation, Climat Tropical, Exercice et Santé
4 Unité Transversale de la Drépanocytose
5 Insern, UMR 763, Hôpital Robert Debré
6 Protéines de la membrane érythrocytaire et homologues non-érythroides
7 Pharmacogénétique et abords thérapeutiques des maladies héréditaires
Abstract : Painful vaso-occlusive crisis (VOC) represents the most frequent complication encountered by SCA patients. In animal models, increased red blood cell (RBC) adhesion to the endothelium has been demonstrated to initiate VOC by increasing the transit time of RBC through the microcirculation, predisposing them to sickle and occlude the vessels (Kaul et al.,
Keywords : sickle cell anaemia vaso-occlusive crisis blood rheology irreversibly sickled cells adhesion
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https://hal.univ-antilles.fr/hal-01968397
Contributor : Marc Romana <>
Submitted on : Wednesday, January 2, 2019 - 4:41:20 PM
Last modification on : Saturday, April 11, 2020 - 2:06:56 AM

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Claudine Lapouméroulie, Philippe Connes, Sara El Hoss, Régine Hierso, Keyne Charlot, et al.. New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso-occlusive crises. British Journal of Haematology, Wiley, In press. ⟨hal-01968397⟩

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