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Effect of CT diversity, synergy and pelleting treatment on in vitro anthelmintic activity against Haemonchus contortus

Abstract : Condensed tannins are known to have anthelmintic properties and can be used in an integrated approach to control gastrointestinal induced pathologies of small ruminants. Pelleting condensed tannins-rich plants allows their availability during the whole year and facilitates their use by farmers. Several authors have shown that condensed tannin profiles differ between plant species and anthelminthic activity can be influenced by the chemical structure of the condensed tannins. To evaluate the effect of condensed tannin diversity, the pelleting process and the combination on anthelmintic properties, this study was conducted on three tropical condensed tannins-rich plants with different tannin profiles using two in vitro assays : the larval development inhibition assay and the larval exsheathment inhibition assay. HPLC profiles and free flavan-3-ol determination were performed on extracts of condensed tannins from plants and pellets. Results showed that anthelmintic properties were dose-dependent and varied according to condensed tannin profiles. A synergistic effect was found only for larval exsheathment. Different compositions of condensed tannins and free flavan-3-ols in the extracts could explain those effects. Pelleting decreased the efficacy of the extracts but did not cancel the anthelmintic activity.
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https://hal.univ-antilles.fr/hal-02513446
Contributor : Eliane Falco <>
Submitted on : Friday, March 20, 2020 - 4:22:06 PM
Last modification on : Saturday, March 21, 2020 - 1:35:16 AM

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  • HAL Id : hal-02513446, version 1

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Nathalie Minatchy, Harry Archimède, Lucien Philibert, Tatiana Silou-Etienne, F. Mounoussamy, et al.. Effect of CT diversity, synergy and pelleting treatment on in vitro anthelmintic activity against Haemonchus contortus. Caribbean Science and Innovation Meeting 2019, Oct 2019, Pointe-à-Pitre (Guadeloupe), France. ⟨hal-02513446⟩

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