β-Globin gene cluster haplotypes and α-thalassemia in sickle cell disease patients from Trinidad - Université des Antilles Access content directly
Journal Articles American Journal of Human Biology Year : 2008

β-Globin gene cluster haplotypes and α-thalassemia in sickle cell disease patients from Trinidad

Altheia Jones-Lecointe
  • Function : Author
Erskine Smith
  • Function : Author
Marie-Georges Gilbert
  • Function : Author
Waveney P Charles
  • Function : Author
Christian Saint-Martin
  • Function : Author
Lisiane Kéclard
  • Function : Author
  • PersonId : 1102554

Abstract

In this study, we have determined the frequency of beta(S) haplotypes in 163 sickle cell disease patients from Trinidad. The alpha(3.7) globin gene deletion status was also studied with an observed gene frequency of 0.17. Among the 283 beta(S) chromosomes analyzed, the Benin haplotype was the most prevalent (61.8%) followed by Bantu (17.3%), Senegal (8.5%), Cameroon (3.5%), and Arab-Indian (3.2%), while 5.7% of them were atypical. This beta(S) haplotypes distribution differed from those previously described in other Caribbean islands (Jamaica, Guadeloupe, and Cuba), in agreement with the known involvement of the major colonial powers (Spain, France, and Great Britain) in the slave trade in Trinidad and documented an Indian origin of the beta(S) gene.

Dates and versions

hal-03265333 , version 1 (22-06-2021)

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Altheia Jones-Lecointe, Erskine Smith, Marc Romana, Marie-Georges Gilbert, Waveney P Charles, et al.. β-Globin gene cluster haplotypes and α-thalassemia in sickle cell disease patients from Trinidad. American Journal of Human Biology, 2008, 20 (3), pp.342-344. ⟨10.1002/ajhb.20732⟩. ⟨hal-03265333⟩
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