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β-Globin gene cluster haplotypes and α-thalassemia in sickle cell disease patients from Trinidad

Abstract : In this study, we have determined the frequency of beta(S) haplotypes in 163 sickle cell disease patients from Trinidad. The alpha(3.7) globin gene deletion status was also studied with an observed gene frequency of 0.17. Among the 283 beta(S) chromosomes analyzed, the Benin haplotype was the most prevalent (61.8%) followed by Bantu (17.3%), Senegal (8.5%), Cameroon (3.5%), and Arab-Indian (3.2%), while 5.7% of them were atypical. This beta(S) haplotypes distribution differed from those previously described in other Caribbean islands (Jamaica, Guadeloupe, and Cuba), in agreement with the known involvement of the major colonial powers (Spain, France, and Great Britain) in the slave trade in Trinidad and documented an Indian origin of the beta(S) gene.
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https://hal.univ-antilles.fr/hal-03265333
Contributor : Marc Romana <>
Submitted on : Tuesday, June 22, 2021 - 1:47:30 PM
Last modification on : Wednesday, June 30, 2021 - 9:40:16 PM

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Altheia Jones-Lecointe, Erskine Smith, Marc Romana, Marie-Georges Gilbert, Waveney Charles, et al.. β-Globin gene cluster haplotypes and α-thalassemia in sickle cell disease patients from Trinidad. American Journal of Human Biology, Wiley, 2008, 20 (3), pp.342-344. ⟨10.1002/ajhb.20732⟩. ⟨hal-03265333⟩

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