Overall survival of triple negative breast cancer in French Caribbean women - Université des Antilles Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2022

Overall survival of triple negative breast cancer in French Caribbean women

Jacqueline Veronique-Baudin
  • Fonction : Auteur
Jonathan Macni
  • Fonction : Auteur
Stephen Ulric-Gervaise
  • Fonction : Auteur
Thierry Almont
Aude Aline-Fardin
  • Fonction : Auteur
Nathalie Grossat
  • Fonction : Auteur
Cristina Furtos
  • Fonction : Auteur
Patrick Escarmant
  • Fonction : Auteur
Vincent Vinh-Hung
  • Fonction : Auteur
Stefanos Bougas
  • Fonction : Auteur

Résumé

To describe survival according to prognostic factors of women with breast cancer in French overseas territory (Martinique) during 2008–2017. We performed a Cox model for prognostic factors for OS in breast cancer patients. The cut-off date for the analysis was 13/10/2018. The main factors were demographic data, stage, hormone receptors (HR) status and HER2 status. Curves were compared with the log rank test to select candidate variables for the multivariate analysis. We included 1,708 patients; median age at diagnosis was 57 years. Triple negative breast cancer (TNBC) accounted for 20.9% (n = 332). Among the patients, 72.3% (n = 1015) had localised or local spread cancer. One-year OS was 95.2% and was 80.1% at 5 years. In TNBC, 1-year-survival was 90.4%, which fell to 70.1% at 5 years. Patients with metastatic disease at diagnosis had 1-year-survival of 74.5%, and 20.1% at 5 years. Multivariate analysis by Cox regression identified 4 factors significantly associated with an increased risk of death: metastatic disease at diagnosis (hazard ratio (HR) = 15, p<0.0001), TNBC (HR 2.84, p<0.0001), HR+/HER2- status (HR 2.05, p<0.0084) and age >75 years (HR 3.8, p<0.0001). This is the first study performed on breast cancer survival in Martinique. Our findings show that breast cancer has overall good prognosis in patients and also how prognosis factors are distributed in the population.
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Dates et versions

hal-03971177 , version 1 (31-05-2023)

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Murielle Murielle Beaubrun-Renard, Jacqueline Veronique-Baudin, Jonathan Macni, Stephen Ulric-Gervaise, Thierry Almont, et al.. Overall survival of triple negative breast cancer in French Caribbean women. PLoS ONE, 2022, 17 (8), pp.e0271966. ⟨10.1371/journal.pone.0271966⟩. ⟨hal-03971177⟩
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