Deep learning of SARS-CoV-2 outbreak phylodynamics with contact tracing data - Université des Antilles Access content directly
Preprints, Working Papers, ... Year : 2024

Deep learning of SARS-CoV-2 outbreak phylodynamics with contact tracing data


Deep learning has emerged as a powerful tool for phylodynamic analysis, addressing common computational limitations affecting existing methods. However, notable disparities exist between simulated phylogenetic trees used for training existing deep learning models and those derived from real-world sequence data, necessitating a thorough examination of their practicality. We conducted a comprehensive evaluation of model performance by assessing an existing deep learning inference tool for phylodynamics, PhyloDeep, against realistic phylogenetic trees characterized from SARS-CoV-2. Our study reveals the poor predictive accuracy of PhyloDeep models trained on simulated trees when applied to realistic data. Conversely, models trained on realistic trees demonstrate improved predictions, despite not being infallible, especially in scenarios where superspreading dynamics are challenging to capture accurately. Consequently, we find markedly improved performance through the integration of minimal contact tracing data. Applying this approach to a sample of SARS-CoV-2 sequences partially matched to contact tracing from Hong Kong yields informative estimates of SARS-CoV-2 superspreading potential beyond the scope of contact tracing data alone. Our findings demonstrate the potential for enhancing deep learning phylodynamic models processing low resolution trees through complementary data integration, ultimately increasing the precision of epidemiological predictions crucial for public health decision making and outbreak control.
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pasteur-04638422 , version 1 (08-07-2024)




Ruopeng Xie, Dillon Adam, Shu Hu, Benjamin Cowling, Olivier Gascuel, et al.. Deep learning of SARS-CoV-2 outbreak phylodynamics with contact tracing data. 2024. ⟨pasteur-04638422⟩
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