Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia

Mona Hedreville; Keyne Charlot; Xavier Waltz; Stéphane Sinnapah; Nathalie Lemonne; Maryse Etienne-Julan; Valérie Soter; Olivier Hue; Marie-Dominique Hardy-Dessources; Jean-Claude Barthélémy; Philippe Connes

doi:10.1371/journal.pone.0095563

Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia

Mona Hedreville ¹ Keyne Charlot ^{1, 2, 3} Xavier Waltz ^{1, 2, 3} Stéphane Sinnapah ¹ Nathalie Lemonne ⁴ Maryse Etienne-Julan ^{2, 3} Valérie Soter ⁵ Olivier Hue ¹ Marie-Dominique Hardy-Dessources ^{2, 3} Jean-Claude Barthélémy ⁶ Philippe Connes ^{1, 2, 7, 3}

1 ACTES - Adaptations au Climat Tropical, Exercice et Santé

2 Laboratory of Excellence GR-Ex "The red cell: from genesis to death"

3 BIGR - Biologie intégrée du globule rouge

4 Unité Transversale de la Drépanocytose

5 CHU Pointe-à-Pitre/Abymes [Guadeloupe]

6 SNA-EPIS - Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé

7 IUF - Institut Universitaire de France

Abstract : A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (,15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.

Keywords : exercice anemia ANS

Type de document :

Article dans une revue

PLoS ONE, Public Library of Science, 2014, 9 (4), pp.e95563. 〈10.1371/journal.pone.0095563〉

Domaine :

Sciences du Vivant [q-bio]

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

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https://hal.univ-antilles.fr/hal-01136725
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Soumis le : vendredi 27 mars 2015 - 21:29:21
Dernière modification le : jeudi 7 février 2019 - 16:32:49
Document(s) archivé(s) le : mardi 18 avril 2017 - 02:31:46

Hedreville et al. - 2014 - Acu...

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