Effect of strenuous physical exercise on circulating cell-derived microparticles

Vicky Chaar 1 Marc Romana 1, 2 Julien Tripette 1, 2 Cédric Broquere 1 Marie-Geneviève Huisse 3 Olivier Hue 2 Marie-Dominique Hardy-Dessources 1 Philippe Connes 2
1 Protéines de la membrane érythrocytaire et homologues non-érythroides
2 ACTES - Adaptations au Climat Tropical, Exercice et Santé
3 Service d'hématologie et immunologie
Abstract : Strenuous exercise is associated with an inflammatory response involving the activation of several types of blood cells. In order to document the specific activation of these cell types, we studied the effect of three maximal exercise tests conducted to exhaustion on the quantitative and qualitative pattern of circulating cell-derived microparticles and inflammatory molecules in healthy subjects. This study mainly indicated that the plasma concentration of microparticles from platelets and polymorphonuclear neutrophils (PMN) was increased immediately after the strenuous exercise. In addition, the increase in plasma concentration of microparticles from PMN and platelets was still observed after 2 hours of recovery. A similar pattern was observed for the IL-6 plasma level. In contrast, no change was observed for either soluble selectins or plasma concentration of microparticles from red blood cells, monocytes and endothelial cells. In agreement, sVCAM-1 and sICAM-1 levels were not changed by the exercise. We conclude that a strenuous exercise is accompanied by platelet-and PMN-derived microparticle production that probably reflects the activation of these two cell types.
Keywords : Microparticles exercise selectins Ig super-familly
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Journal articles
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Submitted on : Monday, June 15, 2015 - 10:06:43 PM
Last modification on : Sunday, March 31, 2019 - 1:22:36 AM

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Vicky Chaar, Marc Romana, Julien Tripette, Cédric Broquere, Marie-Geneviève Huisse, et al.. Effect of strenuous physical exercise on circulating cell-derived microparticles. Clinical Hemorheology and Microcirculation, IOS Press, 2011, 47, pp.15-25. ⟨10.3233/CH-2010-1361⟩. ⟨hal-01163965⟩

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