Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia

Abstract : Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single 12 nucleotide substitution in the ␤-globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin 13 (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading to 14 RBC sickling, hemolysis, vasoocclusion and ultimately to chronic organ damage. The metabolic changes imposed by exercise 15 may initiate sickling and vaso-occlusive episodes. Further, in patients with SCA, exercise limitation may be related to anemia 16 or chronic complications such as pulmonary vascular disease, congestive heart failure and chronic parenchymal lung disease. 17 Few studies have investigated the cardiorespiratory responses of patients with SCA during either symptom-limited maximal 18 exercise test on cyclo-ergometer or during a six minute walk test. Therefore, patients are advised to start exercise slowly and 19 progressively, to maintain adequate hydration during and after exercise, to avoid cold exposure or sudden change in temperature, 20 and to avoid sports associated with mechanical trauma. There are, however, lack of evidence to allow practitioners to prescribe 21 an exercise program for patients with SCA, and individuals are usually encouraged to exercise on a symptom-limited basis. 22 Finally, this review will also highlight the basic principles that are often used for exercise practice and could be used for exercise 23 prescription and rehabilitation in patients with sickle cell anemia.
Type de document :
Article dans une revue
Clinical Hemorheology and Microcirculation, IOS Press, 2011, 48, pp.1-13. 〈10.3233/CH-2011-1465〉
Liste complète des métadonnées

https://hal.univ-antilles.fr/hal-01163966
Contributeur : Philippe Simon <>
Soumis le : lundi 15 juin 2015 - 22:33:24
Dernière modification le : mercredi 26 septembre 2018 - 08:10:07

Identifiants

Collections

Citation

Philippe Connes, Roberto Machado, Olivier Hue, Harvey Reid. Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clinical Hemorheology and Microcirculation, IOS Press, 2011, 48, pp.1-13. 〈10.3233/CH-2011-1465〉. 〈hal-01163966〉

Partager

Métriques

Consultations de la notice

247