Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction?

Keyne Charlot; Marc Romana; Berenike Moeckesch; Stéphane Jumet; Xavier Waltz; Lydia Divialle-Doumdo; Marie Hardy-Dessources; Marie Petras; Benoît Tressieres; Vanessa Tarer; Olivier Hue; Maryse Etienne-Julan; Sophie Antoine-Jonville; Philippe Connes

doi:10.1016/j.bcmd.2015.10.005

Journal articles

Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction?

Keyne Charlot ¹ Marc Romana ² Berenike Moeckesch ¹ Stéphane Jumet ³ Xavier Waltz ⁴ Lydia Divialle-Doumdo ⁵ Marie Hardy-Dessources ¹ Marie Petras ⁵ Benoît Tressieres ⁶ Vanessa Tarer ⁷ Olivier Hue ³ Maryse Etienne-Julan ⁸ Sophie Antoine-Jonville ³ Philippe Connes ^{4, 9}

1 BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge

2 Protéines de la membrane érythrocytaire et homologues non-érythroides

3 ACTES - Adaptation, Climat Tropical, Exercice et Santé

4 DSIMB Réunion - Dynamique des Structures et Interactions des Macromolécules Biologiques - Pôle de La Réunion

BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge

5 Unité Transversale de la Drépanocytose

6 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane

7 Service d'Orthopédie et de Traumatologie

8 Unité Transversale de la Drépanocytose

9 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité

Abstract : Vascular resistance and tissue perfusion may be both affected by impaired vascular function and increased blood viscosity. Little is known about the effects of vascular function on the occurrence of painful vaso-occlusive crises (VOC) in children with sickle cell anemia (SCA). The aim of the present study was to determine which side of the balance (blood viscosity or vascular function) is the most deleterious in SCA and increases the risk for frequent hospitalized VOC. Microvascular function, microcirculatory oxygenation and blood viscosity were determined in a group of 22 SCA children/adolescents at steady state and a group of 13 healthy children/adolescents. Univariate analyses demonstrated blunted microvascular reactivity during local thermal heating test and decreased microcirculatory oxygenation in SCA children compared to controls. Multivariate analysis revealed that increased blood viscosity and decreased microcirculatory oxygenation were independent risk factors of frequent VOC in SCA. In contrast, the level of microvascular dysfunction does not predict VOC rate. In conclusion, increased blood viscosity is usually well supported in healthy individuals where vascular function is not impaired. However, in the context of SCA, microvascular function is impaired and any increase of blood viscosity or decrease in microcirculatory oxygenation would increase the risks for frequent VOC.

Keywords : Microcirculatory oxygenation Microcirculation Hemorheology Sickle cell disease

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Human health and pathology / Hematology

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https://hal.univ-antilles.fr/hal-01668335
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Submitted on : Wednesday, December 20, 2017 - 1:15:10 AM
Last modification on : Thursday, November 5, 2020 - 4:08:56 PM

Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction?

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Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: Blood viscosity or microvascular dysfunction?

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