A model for transfer of P-glycoproteins in MCF-7 breast cancer cell line with multiple transfer rules

Abstract : In this paper, we consider a direct protein transfer process between cells in co-culture. Assuming that cells continually encounter each other, and from some hypotheses on cell-to-cell rules of transfer, we derive discrete and continuous Boltzmann-like integrodifferential equations. The novelty of this model is to take into account multiple transfer rules. This new transfer model is used to fit the experimental data of cell-to-cell protein transfer in breast cancer.
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P. Magal, A. Noussair, J. Pasquier, P. Zongo, F. Le Foll. A model for transfer of P-glycoproteins in MCF-7 breast cancer cell line with multiple transfer rules. Bulletin of Mathematical Biology, Springer Verlag, 2017, 79 (9), pp.2049 - 2067. ⟨10.1007/s11538-017-0319-9⟩. ⟨hal-01683780⟩

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