Oxidative stress, inflammation, blood rheology, and microcirculation in adults with sickle cell disease: Effects of hydroxyurea treatment and impact of sickle cell syndrome - Université des Antilles Access content directly
Journal Articles European Journal of Haematology Year : 2021

Oxidative stress, inflammation, blood rheology, and microcirculation in adults with sickle cell disease: Effects of hydroxyurea treatment and impact of sickle cell syndrome

Philippe Connes
  • Function : Author
Berenike Möckesch
  • Function : Author
Emilienne Tudor Ngo Sock
  • Function : Author
Karen Reminy
  • Function : Author
Sarah Skinner
  • Function : Author
Marie Billaud
  • Function : Author
Elie Nader
  • Function : Author
Benoit Tressieres
  • Function : Author
Maryse Etienne‐julan
  • Function : Author
Nicolas Guillot
  • Function : Author
  • PersonId : 759925
  • IdRef : 190387114
Nathalie Lemonne
  • Function : Author
Olivier Hue
  • Function : Author
Sophie Antoine‐jonville

Abstract

Inflammation and oxidative stress play a key role in the pathophysiology of sickle cell disease (SCD). However, the potential influence of different sickle genotypes, or hydroxyurea (HU) treatment, on these factors remains poorly documented. The present study compared several plasma markers of inflammation and oxidative stress, as well as microvascular function, between patients with sickle SC disease (HbSC, n = 19) and patients with sickle cell anemia (HbSS) under hydroxyurea (HU) treatment (n = 16), or not (n = 13). Hemorheological parameters and levels of inflammatory (IL-6, IL-8, IFN-γ, MCP-1, MIP-1β, TNF-α) and oxidative stress (AOPP, MDA, MPO) markers were determined. Peripheral microcirculatory cutaneous blood flow and immediate microvascular response to local heat were evaluated using laser Doppler flowmetry. Oxidative stress and inflammation were lower in HbSC patients and HbSS patients under HU therapy compared to HbSS patients not treated with HU. Blood viscosity was higher in HbSC than in HbSS patients treated with or not with HU. Vasodilation response of the cutaneous microcirculation to heat stress was higher in HbSS patients receiving HU treatment. Our results clearly established that both sickle cell genotype and HU treatment modulate inflammation and oxidative stress.

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Hematology
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Dates and versions

hal-03265316 , version 1 (26-06-2021)

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Philippe Connes, Berenike Möckesch, Emilienne Tudor Ngo Sock, Marie‐dominique Hardy‐dessources, Karen Reminy, et al.. Oxidative stress, inflammation, blood rheology, and microcirculation in adults with sickle cell disease: Effects of hydroxyurea treatment and impact of sickle cell syndrome. European Journal of Haematology, 2021, 106 (6), pp.800-807. ⟨10.1111/ejh.13607⟩. ⟨hal-03265316⟩
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