Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients - Université des Antilles Access content directly
Journal Articles Blood Cells, Molecules and Diseases Year : 2010

Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients

Danitza Nebor
  • Function : Author
Cédric Broquere
  • Function : Author
Karine Brudey
  • Function : Author
Danielle Mougenel
  • Function : Author
Vanessa Tarer
  • Function : Author
Philippe Connes
Jacques Elion
  • Function : Author

Abstract

The aim of this study was to identify possible risk factors for albuminuria, an early marker of sickle cell anemia (SCA) glomerulopathy, in a cohort of 189 SCA adult patients followed at the Sickle Cell Center of Guadeloupe, a French Caribbean island. Biological parameters obtained at baseline, alpha-globin gene status, and beta(S) haplotypes were compared in patients stratified accordingly to graded albuminuria. Abnormal albumin excretion rate was detected in half of the studied adult patients and macroalbuminuria occurred in 21.6%. Graded albuminuria was associated with advanced age (p=0.006), systolic blood pressure (p=0.031), and worsened anemia, i.e. low hemoglobin rate (p<0.0001) and red blood cell count (p<0.0001). Alpha-thalassemia frequency was lower in microalbuminuric and macroalbuminuric patients than in normoalbuminuric patients, 12.5%, 13.75% and 26%, respectively (p=0.0057). Comparison of albuminuria-free survival curves in SCA patients without and with alpha-thalassemia showed that the median time of albuminuria onset was delayed in the later ones (p=0.021). In contrast, no association of albuminuria was detected with the Bantou beta(S) haplotype. Our results strongly suggest a protective effect of alpha-thalassemia against glomerulopathy in SCA adult patients which could be related to a decreased hemolytic rate.

Dates and versions

hal-03265326 , version 1 (23-06-2021)

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Danitza Nebor, Cédric Broquere, Karine Brudey, Danielle Mougenel, Vanessa Tarer, et al.. Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients. Blood Cells, Molecules and Diseases, 2010, 45 (2), pp.154-158. ⟨10.1016/j.bcmd.2010.06.003⟩. ⟨hal-03265326⟩
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