A comparative study of classic and HIV-viremic and aviremic AIDS Kaposi sarcoma - Université des Antilles Access content directly
Journal Articles AIDS. Official journal of the international AIDS Society Year : 2020

A comparative study of classic and HIV-viremic and aviremic AIDS Kaposi sarcoma

Abstract

Background: Kaposi sarcoma in people living with HIV (PLHIV) is the most common AIDS-associated malignancy. There is increased interest in Kaposi sarcoma in PLHIV with controlled HIV viremia. Objectives: To describe Kaposi sarcoma occurring in PLHIV despite virological control and to compare their clinical presentations with viremic AIDS-Kaposi sarcoma (AIDS-KS) and classic Kaposi sarcoma (CKS). Methods: This was a monocentric retrospective study, including all Kaposi sarcoma patients registered between the 1 January of 2000 and 31 December 2017 in a comprehensive data bank for all cancers in the He ´rault region, South of France. AIDS-KS were also described using chart reviews from the Infectious diseases Department, which followed more than 90% of PLHIV from the same region. We defined aviremic AIDS-KS as Kaposi sarcoma occurring in persons taking HAART with a HIV viral load less than 50 copies for more than 12 months. We compared clinical characteristics of persons with aviremic AIDS-KS, viremic AIDS-KS and CKS, using the Kriegel score and number and topography of skin lesions, and presence of lymphedema. Results: We retrieved 187 Kaposi sarcoma cases, of which 12 occurred in PLHIV with aviremic AIDS-KS. Kriegel score stage I was found in 10 (83%) of the aviremic AIDS-KS, 34 (68%) of CKS and 38 (58.4%) of viremic AIDS-KS cases, with similar clinical presentations between aviremic AIDS-KS and CKS groups, and viremic AIDS-KS persons having more aggressive presentations. One person with aviremic AIDS-KS had visceral involvement. Conclusion: We showed that Kaposi sarcoma in PLHIV with controlled viremia were generally indolent, similarly to CKS. Visceral involvement is, however, possible.
Fichier principal
Vignette du fichier
SEVERIN_2021.pdf (230.42 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-04215045 , version 1 (22-09-2023)

Identifiers

Cite

David Séverin, Faiza Bessaoud, Nadia Meftah, Aurelie Du Thanh, Brigitte Tretarre, et al.. A comparative study of classic and HIV-viremic and aviremic AIDS Kaposi sarcoma. AIDS. Official journal of the international AIDS Society, 2020, 35 (3), pp.399 - 405. ⟨10.1097/qad.0000000000002744⟩. ⟨hal-04215045⟩
51 View
22 Download

Altmetric

Share

Gmail Facebook X LinkedIn More