Article Dans Une Revue Journal of Labelled Compounds and Radiopharmaceuticals Année : 2021

Carbon‐11 carboxylation of terminal alkynes with [ 11 C]CO 2

Carboxylation d'alcynes avec du dioxyde de carbone marqué au carbone-11

Résumé

A copper‐catalysed radiosynthesis of carbon‐11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron‐produced carbon‐11 carbon dioxide ([ 11 C]CO 2 ) in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU). A small library of 11 C‐labelled propiolic acid derivatives were obtained with a total synthesis time of 15 min from end of bombardment (EOB) with a (non‐isolated) radiochemical yield ranging from 7% to 28%.

Domaines

Chimie Radiochimie
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Dates et versions

hal-04688182 , version 1 (04-09-2024)

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Francesca Goudou, Antony D Gee, Salvatore Bongarzone. Carbon‐11 carboxylation of terminal alkynes with [ 11 C]CO 2. Journal of Labelled Compounds and Radiopharmaceuticals, 2021, 64 (6), pp.237-242. ⟨10.1002/jlcr.3907⟩. ⟨hal-04688182⟩

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